Native human heart tissue shows organized cells with easily visible striations
Cells in the microHeart 3D platform exhibit synchronized contractions similar to that in the mammalian heart
Cells aligned in microHeart 2.5D show alignment similar to that of native human heart tissue.
3D imaging showing the physiologic alignment of iPSC-derived cardiomyocytes in microHeart 2.5D
Imaging showing the physiologic alignment of iPSC-derived cardiomyocytes in microHeart 2.5D
microHeart
Structured Cardiomyocytes for High-Throughput Screening
microHeart 3D is comprised of a physiological mixture of human iPSC-derived cardiac cells
The StemoniX microHeart platform provides a structured environment for human induced pluripotent stem cell (iPSC) derived cardiac cells.
In microHeart 2.5D, cells passively align into a physiologically relevant structure that closely represents human heart tissue.
Cardiac cells structured on microHeart 2.5D plates resemble heart tissue alignment, while standard flat cultureware results in a
random arrangement.
In microHeart 3D, cardiomyocytes are structured into cardiospheres with uniform, synchronized beating.
microHeart provides:
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Increased expression of key cardiac physiology genes
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Enhanced organization of sarcomeres
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Distal intercalated discs aligned perpendicularly to fibers
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Coherent directionality of contraction
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Improved calcium handling
microHeart Cell Ready and Assay Ready products provide an ideal model for cardiotoxicity and cardiac safety studies, high-throughput screening, and drug discovery. The microHeart platform can be customized to suit your discovery needs.
