Cells in the microHeart 3D platform exhibit synchronized contractions similar to that in the mammalian heart

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Cells in microHeart 2.5D
show alignment similar to
that of native human heart tissue.

3D imaging showing the physiologic alignment of iPSC-derived cardiomyocytes in microHeart 2.5D

Imaging showing the physiologic alignment of iPSC-derived cardiomyocytes in microHeart 2.5D

microHeart 3D is comprised of a complex mixture of human
iPSC-derived cardiac cells

Native human heart tissue shows organized cells with easily visible striations

microHeart

Structured Cardiomyocytes for High-Throughput Screening

The StemoniX microHeart platform provides a structured environment for human induced pluripotent stem cell (iPSC) derived cardiac cells.

 

In microHeart 2.5D, cells passively align into a physiologically relevant structure that closely represents human heart tissue.
Cardiac cells structured on microHeart 2.5D plates resemble heart tissue alignment, while standard flat cultureware results in a
random arrangement.

In microHeart 3D, cardiomyocytes are structured into cardiospheres with uniform, synchronized beating. 

 

microHeart provides:

  • Increased expression of key cardiac physiology genes

  • Enhanced organization of sarcomeres

  • Distal intercalated discs aligned perpendicularly to fibers

  • Coherent directionality of contraction

  • Improved calcium handling

microHeart Cell Ready and Assay Ready products provide an ideal model for cardiotoxicity and cardiac safety studies, high-throughput screening, and drug discovery. The microHeart platform can be customized to suit your discovery needs.

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