Glioblastoma Multiforme (GBM) is an aggressive brain tumor with a poor prognosis. Therapeutic management for GBM is currently limited with fewer than 20% of patients responding to combination drug/radiation therapy. Moreover, the therapeutics currently used to treat GBM have been shown to be extremely toxic.

 

microBrain 3D spheroids can be co-cultured with mCherry-tagged U87 GBM cells as a traceable model of GBM to study the growth and behavior of GBM in the presence of normal cortical brain tissue.