StemoniX / Molecular Devices Webinar
Due to the structural and functional complexity of the Central Nervous System (CNS), the ability to obtain accurate and predictive in-vitro models for drug discovery and toxicology screening has been lacking. To fill this gap, StemoniX has developed the microBrain 3D platform: pre-plated neural spheroids composed of human iPSC-derived cortical neurons and astrocytes of uniform composition and size.
This presentation will detail how the Molecular Devices FLIPR Penta and ImageXpress Micro Confocal systems have been used to functionally and structurally characterize microBrain 3D spheroids from both healthy and disease sources.
Use of microBrain neuronal microspheroids
Calcium oscillations in neural spheroids
3D image analysis of compound treated neural spheroids
Multi-parametric evaluation of neurotoxicity effects
Virtual Poster Session
The StemoniX microBrain 3D platform was featured in a poster by our partners at
Multiplexed automated assays for neurotoxicity evaluations using induced pluripotent stem cell-derived neural 3D cell models
Simultaneous Assessment of Oncology Compound Efficacy and Toxicity in a Neuronal Human Induced Pluripotent Stem Cell and Glioblastoma-Based High-Throughput Screening Platform
High-Throughput Anisotropic Human iPSC-Derived Cardiomyocyte Cultures Display Differential Response to Chronic Oncology Compound-Related Toxicity
A Novel Objective Waveform Analysis for Providing Bias-free Multiparametric Outputs for Classifying Biological Mechanisms and High-Throughput Screening Results
Assessment of compound efficacy and safety for glioblastoma treatment in a multiplexed human High Throughput Screening platform
A human pancreatic spheroid platform for high throughput screening in toxicology and diabetes
High Throughput profiling of cardio-active compound response between 2D monolayers, anisotropic and 3-dimensional human induced pluripotent stem cell-derived cardiomyocytes