top of page

Morphological and Structural Toxicity

Morphological and structural cues are essential components of a complete data package that enables relevant and meaningful decision-making.  The microBrain platform of complex neural 2D co-cultures or 3D spheroids/organoids cultures enables multiparametric assessment of neurotoxicity and phenotypic characterization across functional, morphological, and structural endpoints.


Our scientific team is well-versed in a variety of high content imaging endpoints that can be customized to fit your specific needs. Standard and confocal imaging and immunocytochemical and staining techniques can be utilized across a variety of endpoints including (but not limited to):

  • Cell population characteristics and subcellular localization

  • Cellular, neurite, and synaptic remodeling

  • Mitochondrial health and nuclear morphology

  • Viability and apoptosis

  • And much, more...


From feasibility assessment to assay development, implementation, and reporting, StemoniX offers a highly customizable, interactive, and transparent process to generate the data that will move your programs forward. 


Contact our scientific team now to identify the best assays for your needs!

Need to move from in vitro to in vivo studies?  Inquire here for early and IND-enabling pre-clinical studies.  

Right: Neurite outgrowth measured using microBrain 3D neural spheroids

RTT neurite outgrowth - 96h - 10X_O09.tif

Below: Synapses investigated using microBrain 2D neural cultures (Image courtesy Front. Cell. Neurosci., 17 October 2019)

Human cells synapses.jpg

Above: Imaging of microBrain 3D neural spheroids shows their complex nature.

bottom of page