top of page

Neurotoxicology Studies

Neurotoxicity continues to be a leading cause of clinical trial failure. In large part, this is attributed to a lack of clinically relevant in vitro models. StemoniX iPSC-based microBrain  platform offers high-throughput access to human-derived complex cultures of neurons and support cells. Testing strategies include acute and chronic exposures with single or repeat dosing strategies as well as molecular, structural, cell health/viability, and functional endpoints to provide a holistic picture of compound impact on neural function.

®

Functional Neurotoxicity
image_preview.png

Spontaneous neural activity from microBrain 3D

Adverse impacts on cell-specific function are often the earliest indication of compound induced toxicity. See how StemoniX provides accurate and reproducible data on neural function in 2D and 3D models.

Cell Health & Viability
Cell Viability Example 2.png

IC50 of rotenone on microBrain 3D

Cell viability is the terminal toxicity endpoint and integral component of any toxicity assessment. We offer several readouts for cell health and viability that can be used in isolation or multiplexed with other assay endpoints.

Morphological &  Structural Toxicity
Morphology Example 1.png

MAP2 (Neurons)

GFAP (Astrocytes)

DAPI (Nuclei)

High-content screening is a key approach to understanding multiple toxicity endpoints. StemoniX scientists employ a variety of standard and confocal-based imaging techniques to provide robust and actionable data.

Gene Expression
clustvisHeatmap.jpg

qPCR analysis

Genetic and epigenetic changes typically underlie long-term and chronic toxicities. These changes are primarily assessed through focused or genome-wide expression analyses.

Neurodevelopmental Toxicity
Slide1.jpeg

StemoniX NPCs

Determine potential developmental neurotoxicity (DNT) effects of your compounds with our in vitro neuro-developmental platform.

bottom of page