Neurotoxicology Studies
Neurotoxicity continues to be a leading cause of clinical trial failure. In large part, this is attributed to a lack of clinically relevant in vitro models. StemoniX iPSC-based microBrain platform offers high-throughput access to human-derived complex cultures of neurons and support cells. Testing strategies include acute and chronic exposures with single or repeat dosing strategies as well as molecular, structural, cell health/viability, and functional endpoints to provide a holistic picture of compound impact on neural function.
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Spontaneous neural activity from microBrain 3D
Adverse impacts on cell-specific function are often the earliest indication of compound induced toxicity. See how StemoniX provides accurate and reproducible data on neural function in 2D and 3D models.

IC50 of rotenone on microBrain 3D
Cell viability is the terminal toxicity endpoint and integral component of any toxicity assessment. We offer several readouts for cell health and viability that can be used in isolation or multiplexed with other assay endpoints.

StemoniX NPCs
Determine potential developmental neurotoxicity (DNT) effects of your compounds with our in vitro neuro-developmental platform.